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个人简介

教育经历: 1984 - 1991 , 博士 , 哈佛医学院 1978 - 1983 , 学士 , 北京医学院 工作经历: 2013- 至 今,北京大学讲席教授,北大-清华生命科学联合中心资深研究员   2013 - 2023 , 院长 , 北京大学生命科学学院 2011 - 2013 , 主任 , 美国加州大学洛杉矶分校分子医学研究所   2009 - 至今 , David Geffen Chair in Medical Research , 美国加州大学洛杉矶分校 2008 - 2011 , 副主任 正式成员 , 美国加州大学洛杉矶分校分子医学研究所 1997 - 2004 , 助理研究员 , 霍华德-休斯医学研究所 1996 - 2013 , 助理教授、副教授、教授 , 美国加州大学洛杉矶分校分子与医学药理学系 1991 - 1996 , 博士后 , 麻省理工学院Whitehead研究所

研究领域

1. PTEN调控干细胞和肿瘤干细胞的分子遗传机制; 2. 前列腺癌单细胞图谱及癌细胞与肿瘤微环境的互作网络绘制; 3. 天然免疫及细胞坏死在前列腺癌进展中的作用机制; 4. 肿瘤发生过程中的代谢重编程

近期论文

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1. Zhu, Haichuan; Dong, Bingjie; Zhang, Yingchi; Wang, Mei; Rao, Jianan; Cui, Bowen; Liu, Yu; Jiang, Qian; Wang, Weitao; Yang, Lu; Yu, Anqi; Li, Zongru; Liu, Chao; Zhang, Leping; Huang, Xiaojun; Zhu, Xiaofan; Wu, Hong. Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia. Blood Science 4, 16-28, doi:10.1097/bs9.0000000000000102 (2022). 2. Xue, Yue; Yang, Ying; Tian, Tao, Quan, Hui; Liu, Sirui; Zhang, Ling; Yang, Lu; Zhu, Haichuan; Wu, Hong; Gao, Yiqin. Computational characterization of domain-segregated 3D chromatin structure and segmented DNA methylation status in carcinogenesis. Mol Oncol 16, 699-716, doi:10.1002/1878-0261.13127 (2022). 3. Zhi, Q., Xu, Z., Zhang, L., Zou, Y., Li, J., Yan, W., Li, C., Liu, N. and Wu, H. Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment. Nat Commun. 2022 Jan 10;13(1):182. PMID: 35013322 4. Yang, L., Chen, F., Zhu, H., Chen, Y., Dong, B., Shi, M., Wang, W., Jiang, Q., Zhang, L., Huang, X., Zhang, M., Wu, H. (2021) 3D Genome Alterations Associated with Dysregulated HOXA13 Expression in High-Risk T-Lineage Acute Lymphoblastic Leukemia. Nat Commun. 2021 Jun 17;12(1):3708. PMID: 34140506 5. Cheng. J., Huang. Y., Zhang. X, Yu. Y., Wu. S., Jiao J., Tran. L., Zhang, W., Liu. R., Zhang, L., Wang. M., Wang, M., Yan, W., Wu, Y., Chi, F., Jiang. P., Zhang. X., and Wu, H.(2020) TRIM21 and PHLDA3 Negatively Regulate the Crosstalk between the PI3K/AKT Pathway and PPP Metabolism. Nat Commun. 20;11(1):1880. PMID: 32312982 6. Wu, Y., Zhu, H., and Wu, H. (2019). PTEN in Regulating Hematopoiesis and Leukemogenesis. Cold Spring Harb Perspect Med. PMID:31712222. 7. Zhu, H., Zhang, L., Wu, Y., Dong, B., Guo, W., Wang, M., Yang, L., Fan, X., Tang, Y., Liu, N., Lei X., and Wu H. (2018). T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1. Elife 7. PMID: 30412053 8. Zou, Y., Qi, Z., Guo, W., Zhang, L., Ruscetti, M., Shenoy, T., Liu, N., and Wu, H. (2018). Cotargeting the Cell-Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kalpha/beta/delta Inhibitor BAY1082439. Mol Cancer Ther 17, 2091-2099. PMID: 30045927 9. Shenoy, T.R., Boysen, G., Wang, M.Y., Xu, Q.Z., Guo, W.L., Koh, F.M., Wang, C., Zhang, L.Z., Wang, Y., Gil, V., Aziz, S., Christova, R., Rodrigues, D.N., Crespo, M., Rescigno, P., Tunariu, N., Riisnaes, R., Zafeiriou, Z., Flohr, P., Yuan, W., Knight, E., Swain, A., Ramalho-Santos, M., Xu, D.Y., de Bono, J. and Wu, H. (2017) CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair. Ann Oncol. Jul 1;28(7):1495-1507.PMID: 28383660 10. Schubbert S., Jiao, J., Ruscetti, M., Nakashima, J., Wu, S., Lei, H., Xu, Q., Yi, W., Zhu, H., Wu, H. (2016) Methods for PTEN in Stem Cells and Cancer Stem Cells Methods Mol. Biol. 1288:233-85. PMID:27033080 11. Ruscetti, M., Dadashian, E.L., Guo, W., Quach, B., Mulholland D.J., Park J.W., Tran, L.M., Kobayashi, N., Bianchi-Frias, D., Nelson, P.S., Xing, Y. and Wu, H. (2016) HDAC Inhibition Impedes Epithelial-Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer. Oncogene. 2016.7.21, 35(29): 3781~3795 PMID:26640144 12. Ruscetti, M., Quach, B., Dadashian, E.L., Mulholland, D.J. and Wu, H. (2015) Tracking and functional characterization of EMT and mesenchymal-like tumor cells in prostate cancer metastasis. Cancer Res. 75:2749-59. PMCID:PMC4490048. 1. 11. Schubbert S, Cardenas A, Chen H, Garcia C, Guo W, Bradner JE, Wu H.  Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T cell acute lymphoblastic leukemia. (2014) Cancer Res74:7048-59.PMCID:PMC4258248 13. 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