NatureๅญๅˆŠ:ๅคๆ—ฆๅคงๅญฆๅญŸไธนๅ›ข้˜Ÿๆญ็คบBACH1่ฐƒๆŽง่‚่„่ƒฐๅฒ›็ด ๆŠตๆŠ—ๆ–ฐๆœบๅˆถ ๆพŽๆนƒๅทยทๆนƒๅฎข ๆพŽๆนƒๆ–ฐ้—ป The Paper

ๅˆ†ๆžๅ•็ป†่ƒž่ฝฌๅฝ•็ป„ๆต‹ๅบๆ•ฐๆฎ(GEO accession no. GSE182365)็š„็ป“ๆžœๆ˜พ็คบ,ไธŽๆญฃๅธธ้ฅฎ้ฃŸ(Chow diet,CD)็›ธๆฏ”,้ซ˜็ณ–้ฅฎ้ฃŸ(HSD)ๅ–‚ๅ…ปๅฐ้ผ ็š„่‚็ป†่ƒžไธญBach1...
ๆพŽๆนƒๆ–ฐ้—ป็ฝ‘

้‡ๅบ†ๅŒป็ง‘ๅคงๅญฆๆจๆขฆๆŸณ/ๆŽไผถ/ๆจๅˆšๆฏ…ๅ›ข้˜Ÿๆๅ‡บ่‚ฅ่ƒ–ๅŠ็›ธๅ…ณไปฃ่ฐข็ดŠไนฑๆฒป็–—ๆ–ฐๆ–นๆณ• ๆพŽๆนƒๅทยทๆนƒๅฎข ๆพŽๆนƒๆ–ฐ้—ป The Paper

ๆจๅˆšๆฏ…ๆ•™ๆŽˆๅŠ้™†ๅ†›ๅ†›ๅŒปๅคงๅญฆ็ฌฌไธ€้™„ๅฑžๅŒป้™ข(่ฅฟๅ—ๅŒป้™ข)ๆŽๆ—ปๅ…ธๆ•™ๆŽˆ็ญ‰,ๅœจ Cell ๅญๅˆŠ Neuron ไธŠๅ‘่กจไบ†้ข˜ไธบ:Reversal of diet-induced obesity by centr...
ๆพŽๆนƒๆ–ฐ้—ป็ฝ‘

ไธญ็ง‘้™ขไธŠๆตท่ฏ็‰ฉๆ‰€ไปป่ฟ›/้™ˆ้™ๅ›ข้˜Ÿๅ‘ๆ–‡:miR-379-5pๆŠ‘ๅˆถ่‚็ป†่ƒžๅ†…ๆธธ็ฆป่ƒ†ๅ›บ้†‡่“„็งฏไปŽ่€Œ็ผ“่งฃ่‚ๆŸไผค mice in Target

่ฟ‘ๆ—ฅ, Molecular Biomedicineๅ‘่กจๆ–‡็ซ โ€œMicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage ...
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Nat Commun (IF=18.1)|้ถๅ‘่‚่„FFAR4ๆ”นๅ–„ไปฃ่ฐข็ดŠไนฑ:ๅคฉ็„ถไบง็‰ฉ่กฅ้ชจ่„‚ๆŸฅๅฐ”้…ฎๆฟ€ๆดปGฮฑqไฟกๅท,ๆ‰“ๆ–ญNr1h3-PPARฮณ่„‚็”Ÿๆˆ่ฝด!(ๆœฑๅ‡้พ™็ญ‰ๅ›ข้˜Ÿ)|ppar|ไป‹ๅฏผ| ๅ…็–ซ|ๅ—ไฝ“| ...

ๅœจๆœฌ็ ”็ฉถไธญ,ไฝœ่€…ๆฏ”่พƒไบ†ไธ‰็ง็ป„็ป‡็‰นๅผ‚ๆ€งFFAR4ๆ•ฒ้™คๅฐ้ผ ๆจกๅž‹ๅœจ้ซ˜่„‚้ฅฎ้ฃŸ(high-fat diet,HFD)่ฏฑๅฏผๅบ”ๆฟ€ไธ‹็š„ไปฃ่ฐขๅ“ๅบ”,ไปฅ่งฃๆžไธป่ฆไปฃ่ฐขๅ™จๅฎ˜ไน‹้—ด็š„ๆฝœ...
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ใ€ŠNeuronใ€‹ๅƒๅ‡บๆฅ็š„่‚ฅ่ƒ–่ƒฝ้€†่ฝฌๅ—?ๆจๆขฆๆŸณ/ๆŽๆ—ปๅ…ธๅˆไฝœๆญ็คบFSTL1้€š่ฟ‡Akt/FoxO1ไฟกๅท้€š่ทฏๆ”นๅ–„ไปฃ่ฐข็š„ๆœบๅˆถ|็ฅž็ปๅ…ƒ|ไธ‹ไธ˜่„‘|foxo|่ƒฐๅฒ›็ด ๆŠตๆŠ—|neuron ็ฝ‘ๆ˜“่ฎข้˜…

diet-induced obesity by central insulin sensitizer FSTL1,ๆญ็คบไบ†้€š่ฟ‡ไธญๆžข่ƒฐๅฒ›็ด ๅขžๆ•ๅ‰‚FSTL1้€†่ฝฌ้ฅฎ้ฃŸ่ฏฑๅฏผ็š„่‚ฅ่ƒ–ใ€‚ ๅตๆณกๆŠ‘็ด ๆ ท่›‹็™ฝ1(FST...
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LOL ๅ“ˆๅ“ˆๅคง็ฌ‘

Jean: ๆˆ‘็ป™ไฝ ๅฟตๅฟตๅฅน็š„็Ÿญไฟกใ€‚ๅฅน็š„็Ÿญไฟก่ฏด: I'm supposed to be on a diet โ€“ don't make me any more delicious cakes ever again! ๅไบ†,็œ‹ๆฅๆˆ‘็œŸๆ˜ฏ...
่‹ฑ่ฏญ็‚นๆดฅ

ๆณจๆ„ ๅƒ็š„ๅฅฝ,็œŸ็š„ๆ›ดๅผ€ๅฟƒ!ๆŠ—ๆŠ‘้ƒ้ฃŸ็‰ฉๅคงๆฏ”ๆ‹ผ,ๆœ€ๆŽจ่ๅƒ่ฟ™ไบ›โ€ฆโ€ฆ Stewart ็บค็ปด ่†ณ้ฃŸ

[5]Gootenberg DB, Button JE, Wolfe BE, et al: Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014;505:559โ€“563. [6]Guu T W, Mischoulon D, Sarris J, et al. International Society for Nutritional Psychiatry Research Practice Guidelines for omega-3 fatty acids in the treatment of major depressive disorder[J]. Psychotherapy an...

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ๅ…ณ็ˆฑๅคง่„‘ ๅฎˆๆŠค่ฎฐๅฟ† ้˜ฟๅฐ”่Œจๆตท้ป˜็—‡ๅ…จๅ‘จๆœŸ็…งๆŠคๆŒ‡ๅ—|็—…็†|็ณ–ๅฐฟ็—…|็ฅž็ปๅ…ƒ|้˜ฟๅ…นๆตท้ป˜็—‡|ๅฟƒ่ก€็ฎก็–พ็—… ็ฝ‘ๆ˜“่ฎข้˜…

ๅฅๅบท็š„้ฅฎ้ฃŸใ€ไธฐๅฏŒ็š„่ฅๅ…ปๆ‘„ๅ…ฅ่ƒฝๅคŸๆœ‰ๆ•ˆๆๅ‡ๆœบไฝ“็š„ๆŠตๆŠ—ๅŠ›ใ€‚ๅœฐไธญๆตท้ฅฎ้ฃŸ(Mediterranean Diet)ๆ˜ฏไธ€็งไปฅๅœฐไธญๆตทๅœฐๅŒบไผ ็ปŸ้ฅฎ้ฃŸๆจกๅผไธบๅŸบ็ก€็š„ๅฅๅบท้ฅฎ้ฃŸๆ–น...
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ๅ†ๆฌก่ขซๆ’ค็จฟ,ๆฐๅ‡บๅญฆ่€…่ขซๆ’คๅ›ž 28 ็ฏ‡ๆ–‡็ซ |diabetes| ๆณณ้“|็ ”็ฉถ่ฎบๆ–‡ ๆ‰‹ๆœบ็ฝ‘ๆ˜“็ฝ‘

Uncoupling Protein-2 by the AMP-activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes10.2337/db08-0...
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ไปŠๆ—ฅNature่š็„ฆๅ…‹็ฝ—ๆฉ็—…+็Ž‹่Œ็ญ‰10ไธชๅŽไบบ/ไธญๅ›ฝๅ›ข้˜Ÿ็ช็ ด ็ƒญๅฟƒ่‚ ๆ—ฅๆŠฅ ็ป†่ƒž niches ่‚ ้“

A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid 2025-11-...
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